[Changes in the level of serum trophoblastic beta 1-globulin in threatened abortion]

The concentrations of trophoblastic b1-globulin (TBG) were measured in the blood sera of 205 healthy women at pregnancy terms of 4 to 40 weeks and in 101 ones with threatened abortions at terms of 5 to 24 weeks. Normal TBG values for each gestation week were derived by regression analysis. TBG levels in women with threatened abortion were compared with the normal values for certain gestation terms and expressed in relative values (% of the normal value). The efficacy of treatment of threatened miscarriage was assessed on the basis of the relative values in 60 women. The results indicate that TBG may be increased or decreased in threatened abortion. Effective therapy leads to normalization of this parameter. A drastic (by several times) drop of TBG level in comparison with the concentration normal for the corresponding pregnancy term sharply increases the risk of an unfavorable outcome.