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Immunopathogenesis and immunotherapy of psoriasis
T W Griffiths1, C E Griffiths, J J Voorhees
1Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314, USA.
Dermatologic Clinics
|October 1, 1995
Summary
Psoriasis pathogenesis involves T-lymphocytes, but the keratinocyte's role is unclear. Future research aims for targeted therapies beyond current immunosuppressants like cyclosporine.
Area of Science:
- Immunology
- Dermatology
- Pharmacology
Background:
- Psoriasis pathogenesis is strongly linked to T-lymphocytes and immune cells.
- The initiating role of keratinocytes in psoriasis hyperproliferation remains uncertain.
- Basic science studies reveal cellular and molecular targets for immunopharmacology.
Purpose of the Study:
- To investigate the potential initiating role of keratinocytes in psoriasis.
- To identify and discuss targeted therapeutic approaches for psoriasis.
Main Methods:
- Review of existing evidence on psoriasis pathogenesis.
- Analysis of cellular and molecular events in keratinocyte hyperproliferation.
- Evaluation of current and emerging immunopharmacological strategies.
Main Results:
- T-lymphocytes are key players in psoriasis development.
- Keratinocyte's role in initiating hyperproliferation requires further investigation.
- Cyclosporine is the most selective immunosuppressant currently available.
Conclusions:
- Further research into immunopathogenesis will enable more selective psoriasis treatments.
- Targeted therapies are advancing with deeper understanding of psoriasis mechanisms.
- Selective immunopharmacological approaches hold promise for future psoriasis management.