Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

VIP modulation of immune cell functions

M De la Fuente¹, M Delgado, R P Gomariz

¹Departamento de Fisiología Animal, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Spain.

Advances in Neuroimmunology

|January 1, 1996

Summary

Vasoactive intestinal peptide (VIP) modulates various immune cell functions, acting as a regulator rather than an inhibitor. This neuropeptide plays a significant role in vivo, influencing immune responses through diverse mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Phase I study of ABM-1310 as monotherapy and in combination with cobimetinib for BRAF-mutated advanced solid tumors: safety, efficacy, and dose expansion.

ESMO open·2026

Same author

Biocompatible self-illuminating sphingomyelin nanosystems for photodynamic-based cancer therapy.

Journal of controlled release : official journal of the Controlled Release Society·2025

Same author

Non-invasive assessment of muscle compartment elasticity by pressure-related ultrasound in pediatric trauma: a prospective clinical study in 25 cases of forearm shaft fractures.

European journal of medical research·2023

Same author

Sex-dependent worsening of NMDA-induced responses, anxiety, hypercortisolemia, and organometry of early peripheral immunoendocrine impairment in adult 3xTg-AD mice and their long-lasting ontogenic modulation by neonatal handling.

Behavioural brain research·2022

Same author

Social environment as a modulator of immunosenescence.

Expert reviews in molecular medicine·2022

Same author

Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields.

Environmental health : a global access science source·2022

Area of Science:

Immunology
Neuroendocrinology
Cell Biology

Background:

Neuropeptides, including vasoactive intestinal peptide (VIP), are increasingly recognized for their immunomodulatory roles.
VIP is released from both nerve endings and immune cells, suggesting a key link between the nervous and immune systems.

Purpose of the Study:

To investigate the multifaceted effects of vasoactive intestinal peptide (VIP) on various immune cell functions.
To explore the potential mechanisms, including receptor heterogeneity, underlying VIP's diverse immunomodulatory actions.

Main Methods:

In vitro analysis of VIP's impact on lymphocyte and macrophage functions.
Assessment of phagocytosis, free radical production, proliferation, lymphokine and immunoglobulin production, and natural killer cell activity.

Main Results:

VIP exhibits differential effects on immune cell functions in vitro, modulating mobility, adherence, and phagocytic activities.
Observed opposite effects of VIP on different immune cell types suggest complex regulatory pathways.

Conclusions:

VIP functions as a modulator, not an inhibitor, of immune responses.
VIP receptor heterogeneity and varied action mechanisms contribute to its diverse effects on immune cells, highlighting its potential in vivo relevance.

Related Experiment Videos