Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect

J R Petrella1, R I Grossman, J C McGowan

  • 1Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.

AJNR. American Journal of Neuroradiology
|June 1, 1996
PubMed
Summary

Magnetization transfer ratios in multiple sclerosis lesions correlate with enhancement patterns. Decreased ratios indicate reduced myelination, improving MRI specificity for assessing lesion extent.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing bone health evaluation in Hermann's tortoises (<i>Testudo hermanni</i>) using spectral detector computed tomography.

Frontiers in veterinary science·2026
Same author

Optimized 3D brachial plexus MR neurography using deep learning reconstruction.

Skeletal radiology·2023
Same author

Canadian Surgery Forum.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons Canadian Hepato-Pancreato-Biliary Society Canadian Society of Surgical Oncology Canadian Society of Colon and Rectal Surgeons: Victoria, BC Sept. 10-13, 2009.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Trends and characteristics in barbiturate deaths Australia 2000-2019: a national retrospective study.

Clinical toxicology (Philadelphia, Pa.)·2020
Same author

The reduction of abnormal behaviors in individually housed rhesus monkeys (Macaca mulatta) with a foraging/grooming board.

American journal of primatology·2020

Area of Science:

  • Neuroimaging
  • Radiology
  • Biomedical Engineering

Background:

  • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • Magnetic Resonance Imaging (MRI) is crucial for diagnosing and monitoring MS.
  • Understanding lesion characteristics is key to assessing disease progression.

Purpose of the Study:

  • To explore the link between the enhancement pattern of MS lesions and their magnetization transfer (MT) effect.
  • To determine if MT ratios can differentiate lesion types based on enhancement.

Main Methods:

  • Analysis of 54 MS lesions from 29 patients using contrast-enhanced T1-weighted MRI.
  • Categorization of lesions into homogeneously enhancing, nonenhancing, and ring-enhancing groups.
  • Measurement of Magnetization Transfer Ratios (MTR) in different lesion types.

Related Experiment Videos

Main Results:

  • Homogeneously enhancing lesions showed higher MTR (32.2%) compared to nonenhancing (29.4%) and ring-enhancing (24.5%) lesions.
  • Significant differences in MTR were observed between ring-enhancing and other lesion types.
  • Lower MTR correlated with enhancement patterns associated with decreased myelin.

Conclusions:

  • A correlation exists between decreased MTR and MS lesion enhancement patterns indicating myelin loss.
  • MT imaging may enhance MRI specificity in evaluating residual myelination in MS lesions.
  • MT technique offers potential for more precise assessment of MS lesion pathology.