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Development of B-cell memory and effector function
1Basel Institute for Immunology, Switzerland. lane@bii.ch
The past year has seen significant advances in our understanding of molecules that both positively and negatively regulate B- and T-cell responses. Of particular interest is the lethal phenotype of CTLA-4-deficient mice, which has illuminated the importance of downregulation of T-cell responses and the increasingly complicated role of CD40 and its ligand in directing both T- and B-cell priming.
The past year has seen significant advances in our understanding of molecules that both positively and negatively regulate B- and T-cell responses. Of particular interest is the lethal phenotype of CTLA-4-deficient mice, which has illuminated the importance of downregulation of T-cell responses and the increasingly complicated role of CD40 and its ligand in directing both T- and B-cell priming.