Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retinoids in lung development

F Chytil1

  • 1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|July 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tissue differences in antigenic properties of non-histone protein-DNA complexes.

Nature: New biology·2010
Same author

Vitamin A status and postnatal dexamethasone treatment in bronchopulmonary dysplasia.

Pediatrics·2000
Same author

Vitamin A: not for vision only.

The British journal of nutrition·2000
Same author

European Consensus Statement on Lung Cancer: risk factors and prevention. Lung Cancer Panel.

CA: a cancer journal for clinicians·1998
Same author

Consensus statement on lung cancer. Lung Cancer Panel.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)·1997
Same author

Safety aspects of vitamin A administration.

European journal of clinical nutrition·1996
Same journal

Utilizing Single-Cell and Transcriptomic Data to Identify Mitochondrial Pathway-Associated Prognostic Genes and Their Regulatory Mechanisms of Action in Ovarian Cancer.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Gene-Environment Interactions in Childhood Asthma: From Prenatal Exposures to Targeted Interventions.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

m6A-Modified KLF11 Inhibits Macrophage Foam Cell Formation by Transcriptionally Suppressing ATP5B Expression in Atherosclerosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Dissecting Allele-Specific Expression (ASE) in Landrace × Meishan Cross Pig Fetal-Placental Tissues: Distribution, Functional Split, and Mechanisms.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Blockade of FGFR1 Trafficking to the Cell Surface Results in the Partial Mistargeting of the Receptor to Peroxisomes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

A Myocyte-Enriched Long Non-Coding RNA NRMLncR Enhances Myogenesis in Mouse.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
See all related articles

Retinoids, like vitamin A, are crucial for lung development and repair. Supplementation aids lung maturation in premature infants and helps heal lungs damaged by oxygen therapy.

Area of Science:

  • Developmental Biology
  • Pulmonary Medicine
  • Nutritional Science

Background:

  • Retinoids significantly impact lung development research.
  • Postnatal lungs are highly sensitive to retinol (R) deficiency, causing epithelial changes.
  • Fetal lungs accumulate retinyl esters, potentially serving as a source for retinoic acid (RA).

Purpose of the Study:

  • To explore the role of retinoids in lung development and maturation.
  • To investigate the effects of retinoic acid (RA) on fetal lung branching and gene expression.
  • To assess the clinical application of vitamin A in premature infants and lung injury.

Main Methods:

  • Observational studies on retinol-deficient animals to assess morphological changes.
  • Analysis of fetal lung development and retinyl ester metabolism.

Related Experiment Videos

  • Clinical application of vitamin A supplementation in premature infants and oxygen-injured lungs.

    • Main Results:

    • Retinol deficiency causes keratinizing metaplasia in the respiratory epithelium, reversible with R supply.
    • Retinoic acid (RA) accelerates fetal lung branching, alveolar tree development, and surfactant protein gene expression.
    • Vitamin A supplementation is used clinically to aid lung development in premature infants and heal oxygen-induced lung injury.

    Conclusions:

    • Retinoids are essential regulators of lung development, influencing epithelial differentiation and branching morphogenesis.
    • Nuclear RA receptors play a critical role in lung development processes.
    • Improving retinol status is a promising strategy for managing immature or injured lungs in clinical settings.