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NCI-Navy Medical Oncology Branch cell line data base

R M Phelps1, B E Johnson, D C Ihde

  • 1National Cancer Institute-Navy Medical Oncology Branch, National Naval Medical Center, Bethesda, Maryland 20897, USA.

Journal of Cellular Biochemistry. Supplement
|January 1, 1996
PubMed
Summary

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A comprehensive cell line database, developed since 1976, offers over 300 human cancer cell lines, primarily for lung cancer research. These valuable biological tools are accessible to the scientific community.

Area of Science:

  • Oncology
  • Cell Biology
  • Biobanking

Background:

  • The National Cancer Institute (NCI) has systematically generated human cell lines since 1976.
  • These cell lines serve as critical biological tools for studying cancer and other diseases.
  • Cell line development is integrated with clinical data and in vitro analyses.

Purpose of the Study:

  • To describe a comprehensive cell line database.
  • To provide researchers with access to a diverse collection of human cancer cell lines.
  • To support cancer research through the provision of well-characterized cell line resources.

Main Methods:

  • Generation of cell lines from clinical specimens under Institutional Review Board-approved protocols.
  • Inclusion of clinical information and in vitro analysis data.

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  • Repository of over 300 human cell lines, including cancer cells and autologous B-lymphoblastoid cells, at the American Type Culture Collection (ATCC).

    • Main Results:

    • A robust database containing clinical and in vitro data for numerous human cell lines.
    • A collection of over 300 human cell lines, with a focus on lung cancer, but also representing a broad range of other cancers.
    • Availability of cell lines and the complete database through the ATCC website.

    Conclusions:

    • The NCI cell line database represents a significant resource for cancer research.
    • The accessibility of these cell lines and associated data facilitates scientific discovery.
    • The long-term effort has resulted in a valuable biobank for the research community.