Clinical experience with the Nikkiso centrifugal pump

Area of Science:

• Cardiovascular Surgery
• Biomedical Engineering
• Medical Devices

Background:

• Preliminary data on the Nikkiso HPM-15 centrifugal pump for cardiopulmonary bypass (CPB) have been previously published.
• Recent clinical applications involved a newly developed controller for enhanced performance.
• This study details expanded clinical experiences with the Nikkiso HPM-15 pump.

Purpose of the Study:

• To evaluate the clinical safety and efficacy of the Nikkiso HPM-15 centrifugal pump.
• To assess the pump's performance in cardiopulmonary bypass (CPB) and percutaneous cardiopulmonary support (PCPS) procedures.
• To report on the ease of use and hemodynamic stability provided by the device.

Main Methods:

• The Nikkiso HPM-15 centrifugal pump was utilized in 23 cases.
• Twenty-two patients underwent CPB, and one patient with fulminant viral myocarditis received PCPS.
• Circuit preparation, deaeration, hemodynamic parameters, serum-free hemoglobin, platelet counts, and renal/liver function were monitored.

Main Results:

• The pump facilitated easy circuit preparation and effective deaeration.
• Stable hemodynamics were maintained throughout CPB and PCPS procedures in all patients.
• Minimal increases in serum-free hemoglobin, transient decreases in platelet count (recovering within 7 days), and high urine output were observed.
• No renal or liver function abnormalities were detected during CPB.

Conclusions:

• The Nikkiso HPM-15 centrifugal pump is safe and user-friendly.
• The pump demonstrates significant utility for both CPB and PCPS applications.
• Clinical outcomes suggest the device is a reliable option for extracorporeal circulatory support.