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Intrinsic neuromodulation: altering neuronal circuits from within

P S Katz1, W N Frost

  • 1Dept of Neurobiology and Anatomy, University of Texas Medical School, Houston, 77030, USA.

Trends in Neurosciences
|February 1, 1996
PubMed
Summary
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Neuromodulation in neuronal circuits stems from extrinsic inputs or intrinsic components. This study clarifies the distinct local effects of intrinsic neuromodulation versus the global effects of extrinsic neuromodulation.

Area of Science:

  • Neuroscience
  • Computational Neuroscience

Background:

  • Neuromodulation influences neuronal circuit function.
  • Two primary sources exist: extrinsic inputs and intrinsic circuit components.
  • Intrinsic neuromodulation is less understood than extrinsic.

Purpose of the Study:

  • To differentiate the properties and effects of intrinsic versus extrinsic neuromodulation.
  • To highlight the significance of intrinsic neuromodulation in various neural circuits.

Main Methods:

  • Comparative analysis of neuromodulatory mechanisms.
  • Review of studies on sensory, neuromuscular, and central pattern generator circuits.

Main Results:

  • Intrinsic neuromodulation causes local changes in neuronal computation.

Related Experiment Videos

  • Extrinsic neuromodulation typically induces global changes across multiple circuits.
  • Evidence for intrinsic neuromodulation is growing across diverse neural systems.

    • Conclusions:

    • Intrinsic and extrinsic neuromodulation represent distinct functional mechanisms.
    • Understanding these differences is crucial for comprehending nervous system dynamics.