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Related Experiment Videos

Paratuberculosis: a potential zoonosis?

R J Chiodini1, C A Rossiter

  • 1International Association for Paratuberculosis, Inc., Rehoboth, Massachusetts, USA.

The Veterinary Clinics of North America. Food Animal Practice
|July 1, 1996
PubMed
Summary

The potential link between Mycobacterium paratuberculosis and Crohn's disease remains uncertain. Decades of research have not definitively established a causal relationship for this controversial association.

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Area of Science:

  • Gastroenterology
  • Microbiology
  • Immunology

Background:

  • Crohn's disease is a chronic inflammatory bowel disease with an unknown etiology.
  • Mycobacterium paratuberculosis (MAP) is a bacterium that causes Johne's disease in ruminants.
  • A controversial hypothesis suggests MAP may play a role in Crohn's disease pathogenesis.

Purpose of the Study:

  • To review the available literature on the role of Mycobacterium paratuberculosis in human Crohn's disease.
  • To assess the evidence for a causal or consequential association between Johne's disease and Crohn's disease.

Main Methods:

  • Literature review of studies investigating Mycobacterium paratuberculosis in Crohn's disease patients.
  • Analysis of epidemiological, microbiological, and immunological data.

Main Results:

  • The available literature presents conflicting evidence regarding the association between MAP and Crohn's disease.
  • Despite extensive investigation over nearly 15 years, a definitive causal link has not been established.

Conclusions:

  • The role of Mycobacterium paratuberculosis as an etiologic agent in Crohn's disease remains controversial and unproven.
  • Further research is needed to clarify the potential association between Johne's disease and Crohn's disease.

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