[1995: a decisive progress for the interlaboratory transferability of results by using enzyme and protein reference...

Transferability of results in clinical enzymology and immunochemistry may be improved by using validated calibrators. For that purpose, certified reference materials (CRM) have been developed. Authors emphasize the need to make known and to use these tools properly, and on the potential efficiency of this approach in immunochemistry with CRM 470, certified for 14 plasma proteins and with enzyme CRMs produced at the international level. They recall the necessity to validate calibrators for specified techniques of measurement used in routine. They also indicate that this approach, if properly conducted, should allow to ensure the transferability of results in enzymology and immunochemistry and thus the clinical efficiency of laboratory results.