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Glucocorticoids and aging

E J Masoro1

  • 1Aging Research and Education Center, University of Texas Health Science Center, San Antonio, USA.

Aging (Milan, Italy)
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Glucocorticoids may drive aging in some species but potentially slow it in others. This review explores their complex role in vertebrate aging and senescence.

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Area of Science:

  • Endocrinology
  • Gerontology
  • Comparative Biology

Background:

  • Glucocorticoids are key stress hormones with diverse physiological roles.
  • Aging is a complex process involving gradual physiological decline.
  • Vertebrate species exhibit varied aging patterns, from rapid post-reproductive decline to gradual senescence.

Purpose of the Study:

  • To review the existing scientific literature on the role of glucocorticoids in vertebrate aging.
  • To investigate the evidence linking glucocorticoid levels to senescence processes.
  • To differentiate the effects of glucocorticoids in semelparous versus iteroparous species.

Main Methods:

  • Literature review of studies on glucocorticoids and aging in vertebrates.
  • Analysis of data on plasma glucocorticoid levels and aging phenotypes.

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  • Comparative assessment across different vertebrate groups and reproductive strategies.

    • Main Results:

    • Strong evidence indicates elevated glucocorticoids cause rapid aging after reproduction in semelparous species.
    • The link between glucocorticoids and gradual aging in most species is less clear.
    • Some evidence suggests moderate glucocorticoid elevations may slow aging in rats, mice, and humans.

    Conclusions:

    • Glucocorticoids can accelerate aging, particularly in species with rapid post-reproductive decline.
    • The role of glucocorticoids in gradual aging is complex and may be protective under certain conditions.
    • Further research is needed to fully elucidate the dual role of glucocorticoids in aging across the vertebrate spectrum.