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Synthesis of oligonucleotides containing a carbocyclic nucleoside
Y Komeda1, K Sakata, H Sugiyama
1Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.
Nucleic Acids Symposium Series
|January 1, 1995
Abstract:
2'-Bromo-substituted cyclopentane-type carbocyclic nucleoside (7a, 7b) was synthesized from sodium cyclopentadienylide. Subsequently, 7a was incorporated into DNA oligomer by means of a conventional phosphoramidite method. Melting-temperature, CD spectra and chemical reaction of such carbocyclic oligonucleotide are described.