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The most electron-donating sites in duplex DNA: guanine-guanine stacking rule
I Saito1, M Takayama, T Nakamura
1Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.
Nucleic Acids Symposium Series
|January 1, 1995
Abstract:
The most readily oxidizable sites in one-electron oxidation of duplex DNA are shown to be the guanine (G) residues located 5' to guanine. Based on experimental results and ab initio calculations, G-G stacking rule has been proposed. This rule indicates the most electron-rich sites contained in B DNA and is very useful for understanding CT interactions between electron-accepting molecules and DNA.