Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA immunization

D E Hassett1, J L Whitton

  • 1Dept of Neuropharmacology, Scripps Research Insitute, La Jolla, CA 92037, USA.

Trends in Microbiology
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

DNA immunization using plasmid DNA vectors triggers immune responses for protection. This method presents a potentially safer and more affordable vaccine alternative, though further research is needed.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intravenous administration of human embryonic stem cell-derived neural precursor cells attenuates cuprizone-induced central nervous system (CNS) demyelination.

Neuropathology and applied neurobiology·2011
Same author

Animal models using lymphocytic choriomeningitis virus.

Current protocols in immunology·2008
Same author

Preferential coxsackievirus replication in proliferating/activated cells: implications for virus tropism, persistence, and pathogenesis.

Current topics in microbiology and immunology·2008
Same author

The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes.

Gene therapy·2003
Same author

Full-length proteins attached to the HIV tat protein transduction domain are neither transduced between cells, nor exhibit enhanced immunogenicity.

Gene therapy·2002
Same author

Designing arenaviral vaccines.

Current topics in microbiology and immunology·2002
Same journal

Host membranes provide hidden gateways for 'accidental pathogens'.

Trends in microbiology·2026
Same journal

Structural inequalities in global antimicrobial resistance governance.

Trends in microbiology·2026
Same journal

Environmental microbes as modulators of plant volatile landscapes: Implications for plant-insect chemical communication.

Trends in microbiology·2026
Same journal

Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools.

Trends in microbiology·2026
Same journal

Cronobacter spp.

Trends in microbiology·2026
Same journal

Anaerobic lignin deconstruction: A game changer for lignocellulosic biorefineries.

Trends in microbiology·2026
See all related articles

Area of Science:

  • Immunology
  • Vaccinology
  • Molecular Biology

Background:

  • Conventional vaccines often elicit strong immune responses but can have limitations.
  • DNA immunization involves introducing plasmid DNA encoding antigens to stimulate immunity.

Purpose of the Study:

  • To explore the potential of DNA immunization as a vaccine strategy.
  • To summarize the immune responses induced by DNA vaccination.

Main Methods:

  • Inoculation with plasmid DNA vectors encoding immunogenic proteins.
  • Assessment of induced humoral and cell-mediated immune responses.

Main Results:

  • Plasmid DNA inoculation successfully induced both humoral and cell-mediated immunity.

Related Experiment Videos

  • The induced immune responses often conferred protective immunity.

    • Conclusions:

    • DNA immunization is a promising vaccine approach.
    • It may offer a safer and more cost-effective alternative to traditional vaccines.
    • Further investigation into mechanism, efficacy, and safety is warranted.