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Related Experiment Videos

Serotonin in alcoholic violent offenders

M Virkkunen1, D Goldman, M Linnoila

  • 1Department of Psychiatry, Helsinki University Central Hospital, Finland.

Ciba Foundation Symposium
|January 1, 1996
PubMed
Summary

Impulsive, violent offenders often have low brain serotonin (5-hydroxytryptamine; 5-HT) turnover, linked to poor impulse control. Genetic analysis of serotonin-regulating genes is ongoing in a Finnish cohort.

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Finnish alcoholic, impulsive, and violent offenders exhibit low brain serotonin (5-hydroxytryptamine; 5-HT) turnover.
  • This low 5-HT turnover is associated with impaired impulse control, suicide attempts, and hyperactivity.
  • High cerebrospinal fluid (CSF) free testosterone is also noted in offenders with antisocial personality disorder.

Purpose of the Study:

  • To investigate the genetic underpinnings of impulsivity and violence in alcoholic offenders.
  • To analyze genes regulating serotonin (5-HT) function in a large Finnish cohort.

Main Methods:

  • Recruited 800 subjects: alcoholic violent offenders, relatives, and male controls from Finland.
  • Collected cerebrospinal fluid (CSF) samples from approximately 200 subjects.
  • Harvested and immortalized leukocytes for genetic analysis, focusing on polymorphisms in tryptophan hydroxylase (TPH) and 5-HT2C receptor genes.

Main Results:

  • Polymorphisms in tryptophan hydroxylase (TPH) and 5-HT2C receptor genes have yielded informative findings.
  • Ongoing genetic analysis aims to identify specific gene variants associated with offender behavior.

Conclusions:

  • Genetic factors, particularly those related to serotonin pathways, likely play a significant role in the development of impulsive and violent behavior in alcoholic offenders.
  • Further research into these genetic associations can inform prevention and treatment strategies.

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