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Related Experiment Videos

American trypanosomiasis (Chagas' disease)

L V Kirchhoff1

  • 1Division of Infectious Diseases, University of Iowa, Iowa City, USA.

Gastroenterology Clinics of North America
|September 1, 1996
PubMed
Summary

Chronic Chagas disease often causes gastrointestinal problems due to nerve damage. Treatments like dilation or surgery can effectively manage symptoms of megaesophagus and megacolon.

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Neurology

Background:

  • Chronic Chagas disease, caused by *T. cruzi* infection, frequently leads to significant gastrointestinal dysfunction.
  • The primary pathology involves progressive, variable denervation of the gastrointestinal tract, affecting different segments over many years.

Purpose of the Study:

  • To review the clinical manifestations and management of gastrointestinal dysfunction in chronic Chagas disease.
  • To highlight the common conditions of megaesophagus and megacolon and their treatment outcomes.

Main Methods:

  • Review of clinical presentations and treatment strategies for gastrointestinal Chagas disease.
  • Analysis of patient outcomes following interventions for megaesophagus and megacolon.

Main Results:

  • Megaesophagus is the most prevalent gastrointestinal manifestation, often relieved by esophageal sphincter dilation or surgery.
  • Megacolon, especially sigmoid involvement, is common and can lead to complications like fecal impaction or volvulus.
  • Surgical resection for advanced megacolon generally yields good postoperative results.

Conclusions:

  • Gastrointestinal complications are a major concern in chronic Chagas disease.
  • Effective management strategies exist for megaesophagus and megacolon, improving patient quality of life.

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