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Clinical mycobacteriology. Drug susceptibility testing
1Mycobacteriology Laboratory, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado, USA.
Clinics in Laboratory Medicine
|September 1, 1996
Summary
This review updates drug susceptibility testing for Mycobacteria tuberculosis, Mycobacteria avium, and rapidly growing mycobacteria. It focuses on current clinical laboratory methods and emerging techniques.
Area of Science:
- Microbiology
- Clinical Diagnostics
- Infectious Diseases
Background:
- Drug susceptibility testing (DST) is crucial for guiding tuberculosis and non-tuberculous mycobacteria treatment.
- Accurate DST ensures effective antimicrobial therapy and prevents the emergence of drug resistance.
- Rapid and reliable DST methods are essential for timely patient management.
Purpose of the Study:
- To provide an updated overview of drug susceptibility testing methods for mycobacteria.
- To highlight techniques currently employed in clinical laboratories.
- To critically evaluate methods under development for mycobacterial DST.
Main Methods:
- Review of current literature and clinical laboratory practices for mycobacterial DST.
- Focus on established methods for Mycobacterium tuberculosis, Mycobacterium avium complex, and rapidly growing mycobacteria.
- Assessment of novel and developmental DST techniques.
Main Results:
- Current clinical laboratories utilize a range of DST methods, including solid and liquid culture-based assays.
- Emerging molecular and automated methods show promise for faster and more accurate DST.
- Standardization and validation of new methods are ongoing.
Conclusions:
- Existing DST methods provide essential information for patient care.
- Advancements in technology are leading to more efficient and precise diagnostic tools.
- Continued research and development are vital for improving mycobacterial drug susceptibility testing.