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Updated: Aug 18, 2026

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
Published on: April 21, 2014
[Disorders of intraventricular conductivity in primary myocardial infarct]
Insights
Acute myocardial infarction frequently causes His bundle branch blocks, impacting heart conductivity. These blocks correlate with other rhythm disorders, highlighting the link between cardiac conductivity and excitation.
Area of Science:
- Cardiology
- Electrophysiology
- Internal Medicine
Background:
- Intraventricular conductivity plays a crucial role in cardiac function.
- Acute primary myocardial infarction can significantly disrupt normal heart electrical pathways.
Abstract:
Recent knowledge of the system of intraventricular conductivity permits to diagnose much more often the different variants of blocks of the main branches of the bundle of His that develop in acute primary myocardial infarction (41.42%). Clinical and electrocardiographic examinations of 239 patients with acute primary myocardial infarction revealed unilateral conductivity disorders in the right ventricle in 19.24% of the cases, in the left ventricle -- in 13.39%, and bilateral conductivity disorders -- in 8.79%. The main branches of the bundle of His blocks were combined with atrioventricular conductivity disorders in 19 patients (20.21%), in 12 of them the atrioventricular block being a manifestation of bilateral intraventricular conductivity disorders. Patients with various conductivity disorders developed with significantly higher incidence other rhythm disorders (atrial flutter and fibrillation, paroxysmal tachycardia), which indicates to a close relationship between the functions of conductivity and excitation of the heart.
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