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Analysis of ibuprofen in serum by capillary electrophoresis
1Department of Pathology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
Journal of Chromatography. B, Biomedical Applications
|August 9, 1996
Abstract:
A rapid method for analysis of the analgesic drug ibuprofen in serum by capillary zone electrophoresis in a borate buffer 160 mmol/l pH 8.5 is described. The method involves deproteinization with acetonitrile to remove serum proteins followed by direct injection on the capillary. The recoveries of standards added to the serum were 84-92%. The method is suited for analysis of samples with concentrations > 10 mg/l. Many other analgesics such as ketoprofen, daypro and salicylates can also be determined by this method.