Related Experiment Videos
Synthesis of 4,17-diazasteroid inhibitors of human 5 alpha-reductase
J W Morzycki1, Z Lotowski, A Z Wilczewska
1Institute of Chemistry, University of Warsaw, Białystok Branch, Poland.
Bioorganic & Medicinal Chemistry
|August 1, 1996
Abstract:
The synthesis of the 17-aza isomer of finasteride is described. With the side chain amide group of the compound existing in the Z configuration the structure is similar to one of the two favored conformations of finasteride. A series of 4,17-diazasteroids was assayed against the isoenzymes of human 5 alpha-reductase.