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Pediatric Devic's neuromyelitis optica

A R Jeffery1, J R Buncic

  • 1Hospital for Sick Children, University of Toronto, Ontario, Canada.

Journal of Pediatric Ophthalmology and Strabismus
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

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Pediatric neuromyelitis optica (Devic's disease) presents uniquely in children, with most experiencing bilateral optic neuritis and rapid recovery. This study indicates an excellent prognosis for visual and neurological outcomes in pediatric cases.

Area of Science:

  • Neurology
  • Ophthalmology

Background:

  • Neuromyelitis optica (Devic's disease) is a rare autoimmune condition typically affecting adults, characterized by optic neuritis and transverse myelitis.
  • Pediatric cases of Devic's disease are infrequently reported, and their distinct clinical profiles and prognoses remain under-characterized.

Observation:

  • This study reviewed nine pediatric cases of neuromyelitis optica over 15 years, alongside a literature search of other pediatric cases.
  • The average age of onset was 7 years, with all patients presenting with a preceding viral prodrome.
  • Optic neuritis was bilateral in 89% of cases, with initial visual loss varying from 20/30 to light perception.

Findings:

  • Patients exhibited rapid visual and neurological recovery, with an average follow-up of 5.3 years.
  • None of the nine pediatric patients experienced recurrence or significant long-term sequelae.

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  • Visual follow-up revealed 20/20 vision in all patients, with mild optic atrophy noted in 47% of eyes.

    • Implications:

    • Devic's disease in children represents a distinct clinical entity with a favorable prognosis for both visual and systemic recovery.
    • The findings suggest that pediatric neuromyelitis optica does not typically lead to long-term visual impairment or neurological deficits.