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Related Experiment Videos

Transurethral hyperthermia for benign prostatic hyperplasia: long term results

Z Petrovich1, M C Pike, S D Boyd

  • 1Department of Radiation Oncology, University of Southern California School of Medicine, Los Angeles 90033, USA.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
|September 1, 1996
PubMed
Summary

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Transurethral hyperthermia (TUHT) offers an effective, low-toxicity alternative for benign prostatic hyperplasia (BPH) patients refusing surgery. This treatment demonstrated significant symptom improvement and durable results in a phase I trial.

Area of Science:

  • Urology
  • Minimally Invasive Therapies
  • Medical Devices

Background:

  • Transurethral resection of the prostate (TURP) is the standard treatment for benign prostatic hyperplasia (BPH).
  • An alternative treatment is needed for patients who decline TURP.
  • Transurethral hyperthermia (TUHT) was investigated as a potential alternative.

Purpose of the Study:

  • To evaluate the safety and efficacy of Transurethral hyperthermia (TUHT) in patients with benign prostatic hyperplasia (BPH).
  • To assess TUHT as an alternative treatment for patients unwilling to undergo Transurethral resection of the prostate (TURP).

Main Methods:

  • A phase I trial involving 21 BPH patients with moderate to severe symptoms treated with TUHT.
  • TUHT sessions averaged 8.4 sessions of 60 minutes each, maintaining urethral temperatures between 40.3°C and 49.2°C.

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  • Patient outcomes were assessed using subjective (Total Symptom Score) and objective (Peak Flow Rate, Post-Voiding Residual Volume, Prostate Volume) parameters.

    • Main Results:

    • TUHT demonstrated excellent tolerance with minor, transient acute toxicity (71% of patients) and no late complications.
    • Significant improvements were observed at 6 months: 81% showed objective improvement and 71% subjective improvement.
    • Long-term follow-up showed sustained response in 9 out of 17 patients for over six years, with two relapses.

    Conclusions:

    • Transurethral hyperthermia (TUHT) is an effective treatment for benign prostatic hyperplasia (BPH) with minimal toxicity.
    • TUHT offers a viable alternative to Transurethral resection of the prostate (TURP) for select patients.
    • Further prospective randomized trials are recommended to establish the definitive role of TUHT in BPH management.