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Published on: September 23, 2015
Regulation of glutamic acid decarboxylase mRNA expression in rat brain after sertraline treatment
L Giardino1, M Zanni, C Bettelli
1Inst. of Otolaryngol. II, Milano University, Italy. cefisnmo@mbox.vol.it
Abstract:
We now investigated the effect of chronic treatment with sertraline on glutamic acid decarboxylase mRNA expression in different rat brain areas by means of in situ hybridization. We found a reduced glutamic acid decarboxylase mRNA expression in the prefrontal cortex, accumbens nucleus, olfactory tubercle and reticular nucleus of the thalamus. The involvement of presynaptic modulation of gamma-amino-butyric acid transmission in the anxiolytic effect of sertraline is discussed.
