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Clinical review of nasal allergy due to fungus
1Department of Otolaryngology, Nagoya City University Medical School, Japan.
Abstract:
In our clinic we have encountered nasal allergy due to fungi such as Candida, Aspergillus, and Alternaria. We therefore conducted a retrospective study of patients who consulted our Department between 1984 and 1991. A clinical review of patients who showed a positive skin test for Candida, Aspergillus, or Alternaria was performed. Our study revealed that Alternaria showed the highest ratio of strong positivity upon both RAST and skin test among the three fungi examined. These results led us to reconsider Alternaria as an important fungal antigen.
Insights
Nasal allergies are often caused by fungi. This study found Alternaria fungus showed the strongest allergic reaction in patients, suggesting it
Area of Science:
- Allergy and Immunology
- Mycology
- Clinical Medicine
Background:
- Nasal allergies can be triggered by various fungal species.
- Commonly implicated fungi include Candida, Aspergillus, and Alternaria.
Purpose of the Study:
- To investigate the role of specific fungi in causing nasal allergies.
- To compare the allergic potential of Candida, Aspergillus, and Alternaria.
Main Methods:
- Retrospective study of patients consulting a specialized department between 1984-1991.
- Clinical review and skin testing for fungal allergens.
- Radioallergosorbent test (RAST) used for further validation.
Main Results:
- Alternaria demonstrated the highest ratio of strong positivity in both skin tests and RAST.
- Candida and Aspergillus also showed positivity but to a lesser extent.
- Alternaria emerged as a significant fungal antigen in this patient cohort.
Conclusions:
- Alternaria is a key fungal antigen implicated in nasal allergies.
- Further consideration of Alternaria in allergy diagnosis and management is warranted.
- Fungal allergens play a crucial role in allergic rhinitis.