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Chronological changes in bone mineral content following gastrectomy
Z Nihei1, K Kojima, W Ichikawa
1Second Department of Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Japan.
Surgery Today
|January 1, 1996
Summary
Gastrectomy significantly impacts bone mineral density, with a sharp decrease observed 1-2 years post-surgery. Early intervention is crucial for treating metabolic bone disease following this procedure.
Area of Science:
- Endocrinology
- Gastroenterology
- Orthopedics
Background:
- Metabolic bone disease is a recognized complication after gastrectomy.
- Quantitative assessment of bone mineral content has advanced.
- Awareness of post-gastrectomy bone complications is increasing.
Purpose of the Study:
- To evaluate the effect of gastrectomy on bone mineral density.
- To identify the timeline of bone mineral content changes after gastrectomy.
- To determine the optimal timing for intervention in post-gastrectomy bone disease.
Main Methods:
- Quantitative computed tomography (QCT) was used to examine 98 postgastrectomy patients.
- Bone mineral density index (BMDI) was calculated by comparing patient bone density to age- and sex-matched controls.
- BMDI values were analyzed based on time elapsed since gastrectomy, patient sex, and gastrectomy type.
Main Results:
- The overall BMDI in postgastrectomy patients was 80.4 +/- 27.3.
- BMDI showed no significant difference between sexes or gastrectomy types.
- A significant decrease in BMDI was observed 1-2 years after gastrectomy, indicating a critical window for intervention.
Conclusions:
- Gastrectomy-induced changes in bone metabolism occur within the first two years.
- Bone mineral content declines significantly after this initial two-year period.
- Therapeutic interventions for bone disease post-gastrectomy are most effective when initiated early after surgery.