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Is there a causal connection between bile acids and colorectal cancer?
1First Department of Surgery, University of Rome "La Sapienza," Viale del Policlinico, Italy.
Surgery Today
|January 1, 1996
Abstract:
Bile acid composition was assessed in 50 patients with colorectal cancer as compared to that in a control group of 50 subjects. The two groups were age- and sex-matched. The overall bile acid values were similar in both groups, while the relative concentrations of primary and secondary bile acids were different, a significant increase in the patients with colorectal cancer being observed. This finding thus seems to confirm the existence of a link between colorectal cancer and cholelithiasis. Both conditions share common risk factors, such as alterations in cholesterol metabolism and bile acid composition.