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[Antibiotic-induced prolonged cholestasis: suspected induction by ceftibuten]
1Medizinische Poliklinik, Ludwig-Maximilians-Universität München.
Zeitschrift Fur Gastroenterologie
|July 1, 1996
Summary
Ceftibuten treatment for Pseudomonas aeruginosa otitis externa in a diabetic patient led to prolonged, irreversible cholestasis. The patient later died from antibiotic-resistant Pseudomonas sepsis.
Area of Science:
- Pharmacology
- Hepatology
- Infectious Diseases
Background:
- Otitis externa is an infection of the ear canal.
- Pseudomonas aeruginosa is a common cause of otitis externa, particularly in diabetic patients.
- Ceftibuten is a third-generation cephalosporin antibiotic used to treat bacterial infections.
Observation:
- A 43-year-old diabetic female presented with Pseudomonas aeruginosa-induced otitis externa.
- The patient was treated with ceftibuten.
- Following treatment, she developed a seven-month-persisting, irreversible cholestasis.
Findings:
- Liver biopsy showed canalicular and hepatocellular cholestasis.
- No liver cell necrosis or bile duct injury was observed.
- The patient succumbed to antibiotic-resistant Pseudomonas septicemia after seven months.
Implications:
- Ceftibuten may be associated with prolonged cholestasis in diabetic patients.
- This case highlights the potential for severe, irreversible liver injury from antibiotic treatment.
- The development of antibiotic-resistant Pseudomonas strains poses a significant clinical challenge.