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Reflex peripheral vasoconstriction is diminished in older men

W L Kenney1, C G Armstrong

  • 1Noll Physiological Research Center, The Pennsylvania State University University Park, PA 16802-6900, USA.W7K@PSU.EDU

Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 1, 1996
PubMed
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Older men exhibit a reduced reflex vasoconstrictor response to whole body cooling compared to younger men. This age-related difference in limb blood flow control is independent of fitness or body composition.

Area of Science:

  • Physiology
  • Thermoregulation
  • Aging Research

Background:

  • Thermoregulatory reflexes control limb blood flow.
  • Age may influence the effectiveness of these reflexes.

Purpose of the Study:

  • To compare reflex control of limb blood flow between young and older men during whole body cooling.
  • To determine if age per se affects vasoconstrictor responses.

Main Methods:

  • Young (n=6) and older (n=6) men, matched for VO2max and body composition, underwent whole body cooling.
  • Forearm blood flow (FBF) was measured using plethysmography with localized arm warming to isolate reflex control.
  • Skin and esophageal temperatures were monitored throughout the 2-hour cooling protocol.

Main Results:

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  • Both groups experienced similar decreases in mean skin temperature.
  • Younger men initially maintained higher FBF but showed a greater reduction during cooling.
  • Older men exhibited a significantly lower FBF during the final cooling phase, indicating a diminished vasoconstrictor response.

Conclusions:

  • Older men have a diminished reflex limb vasoconstrictor response to skin cooling.
  • This age-related difference in peripheral blood flow control is likely due to chronological age, not fitness or body composition.