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Related Experiment Videos

Desmosomes: differentiation, development, dynamics and disease

D Garrod1, M Chidgey, A North

  • 1Epithelial Morphogenesis Research Group, School of Biological Sciences, University of Manchester, 3.239 Stopford Building, Oxford Road, Manchester M13 9PT, UK. David.Garrod@man.ac.uk

Current Opinion in Cell Biology
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

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Desmosomes, crucial for epithelial cell adhesion, are involved in tissue development and diseases. Their glycoprotein isoforms play a key role in cell differentiation and morphogenesis, impacting conditions like cancer.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Dermatology

Background:

  • Desmosomes are vital cell-cell adhesion structures in epithelial tissues.
  • Desmosomal glycoprotein isoforms are key components of these adhesion complexes.
  • Previous research suggested desmosomes' role in epithelial organization.

Purpose of the Study:

  • To investigate the distribution and function of desmosomal glycoprotein isoforms.
  • To understand how cellular interactions and signaling pathways affect desmosome adhesion.
  • To explore the implications of desmosomal components in diseases.

Main Methods:

  • Analysis of desmosomal glycoprotein isoform expression patterns.
  • Studies on cellular interactions modulating desmosome function.

Related Experiment Videos

  • Investigation of protein kinase C (PKC) effects on desmosome adhesion.

    • Main Results:

    • Combined expression of desmosomal glycoprotein isoforms within individual desmosomes was observed.
    • Cellular interactions and PKC activity were found to modulate desmosome adhesive properties.
    • Genetic evidence links desmosomal components to cancer and epidermal diseases.

    Conclusions:

    • Desmosomal glycoprotein isoforms are integral to epithelial differentiation and morphogenesis.
    • Desmosome function is dynamically regulated by cellular context and signaling.
    • Dysregulation of desmosomal components has significant implications for human health, particularly in cancer and skin disorders.