Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrin cytoplasmic interactions and bidirectional transmembrane signalling

S Dedhar1, G E Hannigan

  • 1Department of Medical Biophysics Division of Cancer Biology Research, Sunnybrook Health Science Centre, Reichmann Research Building, S-218, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.

Current Opinion in Cell Biology
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.

Oncogene·2017
Same author

Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression.

Oncogene·2015
Same author

Serum integrin-linked kinase (sILK) concentration and survival in non-small cell lung cancer: a pilot study.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2013
Same author

Selective regulation of p38β protein and signaling by integrin-linked kinase mediates bladder cancer cell migration.

Oncogene·2013
Same author

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.

Oncogene·2012
Same author

Role of the integrin-linked kinase (ILK)/Rictor complex in TGFβ-1-induced epithelial-mesenchymal transition (EMT).

Oncogene·2012
Same journal

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
See all related articles

Integrins are cell receptors that control cell adhesion and migration. Their cytoplasmic domains interact with proteins to transmit signals, influencing cell behavior and growth factor responses.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Integrins are vital plasma membrane proteins mediating cell adhesion and migration.
  • They facilitate bidirectional signal transduction across the cell membrane.
  • Integrin function is crucial for cellular communication and organization.

Purpose of the Study:

  • To explore the role of integrin cytoplasmic domains in signal transduction.
  • To identify novel protein interactions involving integrin cytoplasmic domains.
  • To understand how integrins coordinate cellular responses to external stimuli.

Main Methods:

  • Investigating protein-protein interactions of integrin cytoplasmic domains.
  • Analyzing signal transduction pathways activated by integrins.

Related Experiment Videos

  • Studying the coordination of actin cytoskeleton and growth factor responses.

    • Main Results:

    • Integrin cytoplasmic domains interact with novel proteins like integrin-linked kinase and beta3 endonexin.
    • Evidence suggests integrin cytoplasmic domains coordinate actin organization via focal adhesion kinase.
    • Integrins exhibit unique properties as signal transducing receptors.

    Conclusions:

    • Integrin cytoplasmic domains are key players in intracellular signal transduction.
    • Integrin interactions with cytoplasmic proteins regulate cell behavior and responses.
    • Further research into integrin signaling pathways is essential for understanding cell function.