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Pre-injection fluorescence in indocyanine green angiography
F C Piccolino1, L Borgia, E Zinicola
1University Eye Clinic of Genoa, Italy.
Ophthalmology
|November 1, 1996
Summary
Infrared pre-injection fluorescence is common in patients undergoing indocyanine green (ICG) angiography, often originating from chorioretinal lesions. Recognizing this autofluorescence prevents misinterpreting ICG angiograms.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Indocyanine green (ICG) angiography is crucial for diagnosing chorioretinal disorders.
- Potential artifacts in ICG angiography can lead to misinterpretations.
- Understanding pre-injection fluorescence is key to accurate diagnostic imaging.
Purpose of the Study:
- To determine the prevalence of infrared pre-injection fluorescence in patients undergoing ICG angiography.
- To identify the sources and characteristics of this pre-injection fluorescence.
- To assess the clinical significance of pre-injection fluorescence in ICG interpretation.
Main Methods:
- Infrared fundus photography was performed before ICG injection in 450 patients.
- A high-resolution videoangiography system with specific ICG filters was utilized.
- Standard ICG angiography protocols were followed, with maximum flash intensity.
Main Results:
- Pre-injection fluorescence was observed in 40.8% of patients (184/450).
- Strong fluorescence (simulating vascular filling) occurred in 75 patients; faint fluorescence in 109.
- Sources included subretinal hemorrhages, lipofuscin-like deposits, pigmented choroidal neovascular membranes, and chronic serous detachments.
Conclusions:
- Pre-injection fluorescence is a frequent finding in eyes requiring ICG examination.
- This phenomenon, likely autofluorescence from ocular pigments, can mimic pathologies.
- Pre-injection infrared imaging aids in avoiding misinterpretation of ICG angiograms.