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Progressive detachment of cells from surfaces: a consequence of heterogeneous ligand populations or a multi-site
J Hubble1, F Ming, R Eisenthal
1School of Chemical Engineering, University of Bath, U.K.
Journal of Theoretical Biology
|September 21, 1996
Abstract:
A multi-site binding equilibrium model is proposed to describe the effect of applied shear on the detachment of affinity adsorbed particles or cells from surfaces. Unlike earlier models used to describe this phenomenon the current approach considers the extent to which multiple interactions show surface cooperativity such that the attached fraction can be described in terms of a number of subpopulations linked via differing numbers of ligand/receptor interactions.