Effect of monoclonal antibody on the adhesion of platelets to aortic segments

A purified monoclonal antibody raised against a purified platelet 65 kDa protein that binds to type I collagen receptor was used to see if the antibody can block the adhesion of platelets to damaged aortic segments. The purified antibody binds to the surface of human platelets by flow cytometry. The adhesion of platelets to the damaged aortic segments was significantly reduced by the pre-incubation of the platelet-rich plasma with the antibody, suggesting that the antibody binds to platelets and blocks the adhesion of platelets to the aortic segments.