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Related Experiment Videos

A microstructural flow analysis within a bileaflet mechanical heart valve hinge

J M Gross1, M C Shu, F F Dai

  • 1Medtronic Heart Valves, Inc., Irvine, CA 92614, USA.

The Journal of Heart Valve Disease
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

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Flow analysis revealed complex flow patterns and stagnation zones within the Medtronic Parallel mechanical heart valve hinges, contributing to thrombus formation. This study offers a new method for assessing future mechanical heart valve designs for thrombosis risk.

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Cardiovascular Research

Background:

  • Medtronic Parallel bileaflet heart valve demonstrated high thrombosis rates in clinical trials.
  • Patient and material factors did not explain the high complication rate.
  • Hypothesis: Hinge pocket flow fields contribute to thrombus formation.

Purpose of the Study:

  • Investigate the microstructural flow within the mechanical heart valve hinge pocket.
  • Identify flow characteristics associated with thrombus formation.
  • Establish a method for evaluating future mechanical heart valve designs.

Main Methods:

  • Utilized flow visualization, computational fluid dynamics (CFD), and laser Doppler velocimetry (LDV).
  • Employed dimensionally accurate transparent heart valve housings.

Related Experiment Videos

  • Leveraged advancements in CFD and LDV measurement techniques.

    • Main Results:

    • Identified an inflow channel vortex during forward flow and disturbed 3D flow during reverse flow.
    • Observed turbulent shear stress zones capable of causing blood cell damage.
    • Detected flow stagnation and disturbed flow along the leaflet pivot throughout the cardiac cycle.
    • Clinical explant data supported analysis predictions of thrombus formation sites.

    Conclusions:

    • Provided novel insights into detailed flow structures within mechanical heart valve hinges.
    • Demonstrated a viable analysis technique for assessing thrombosis potential in new valve designs.
    • Highlighted the critical role of hinge region hemodynamics in valve performance and safety.