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Bone disorders in sickle cell disease

J A Smith1

  • 1Comprehensive Sickle Cell Center, Harlem Hospital/Columbia University, New York, New York, USA.

Hematology/Oncology Clinics of North America
|December 1, 1996
PubMed
Summary
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Sickle cell disease frequently affects the skeleton, causing complications like bone marrow necrosis and osteomyelitis. Understanding these bone issues is crucial for effective patient care.

Area of Science:

  • Orthopedics
  • Hematology
  • Pathology

Background:

  • Sickle cell disease (SCD) commonly leads to skeletal complications due to sickling.
  • Bone marrow necrosis, osteomyelitis, and aseptic necrosis are prevalent in SCD patients.

Purpose of the Study:

  • To highlight the importance of understanding SCD-related bone complications.
  • To provide insights into the pathogenesis, prevalence, diagnosis, and management of these conditions.

Main Methods:

  • Review of existing literature on skeletal complications in sickle cell disease.
  • Analysis of common pathological findings and diagnostic approaches.

Main Results:

  • Skeletal complications are a significant manifestation of sickle cell disease.

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  • Early diagnosis and appropriate management are key to improving outcomes.

    • Conclusions:

    • A comprehensive understanding of SCD's skeletal impact is essential for clinicians.
    • Addressing bone complications improves the quality of life for patients with sickle cell disease.