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Gliomatosis cerebri presenting with optic nerve involvement: MRI
G J Felsberg1, J P Glass, R D Tien
1Department of Radiology (Box 3808), Duke University Medical Center, Durham 27710, USA.
Neuroradiology
|November 1, 1996
Summary
Gliomatosis cerebri, a rare astrocytoma, infiltrates the brain extensively with subtle symptoms. MRI revealed optic nerve and chiasm involvement, confirming the diagnosis through biopsy.
Area of Science:
- Neuro-oncology
- Neuroradiology
- Neuropathology
Background:
- Gliomatosis cerebri is a rare, diffuse astrocytoma with extensive brain infiltration.
- It often presents with nonspecific clinical symptoms, complicating early diagnosis.
Observation:
- This case details a patient with gliomatosis cerebri presenting with optic nerve and chiasm involvement.
- Contrast-enhanced MRI demonstrated enlarged optic pathways with abnormal enhancement.
- T2-weighted MRI revealed widespread tumor infiltration throughout the brain.
Findings:
- Histopathology confirmed an anaplastic astrocytoma with gemistocytic features.
- The findings supported a diagnosis of gliomatosis cerebri.
Implications:
- This case highlights the importance of advanced neuroimaging in diagnosing rare brain tumors.
- Understanding MRI characteristics is crucial for identifying gliomatosis cerebri, even with atypical presentations.
- Accurate diagnosis impacts treatment strategies for this challenging condition.