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Related Experiment Videos

Imaging in clinical trials

H A Bird1

  • 1Clinical Pharmacology Unit, Chapel Allerton Hospital, Leeds, UK.

Bailliere'S Clinical Rheumatology
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Imaging plays a key role in antirheumatic drug trials. While advanced imaging offers sensitivity for early changes, conventional radiology remains prevalent due to cost and accessibility in large multicenter studies.

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Area of Science:

  • Rheumatology
  • Medical Imaging
  • Clinical Pharmacology

Background:

  • Imaging is crucial for evaluating antirheumatic drug efficacy in clinical trials.
  • Rapid efficacy assessment often limits the use of traditional radiological evaluation in chronic arthritis.
  • There is a need for advanced imaging techniques to detect subtle, early changes, especially between drugs of similar potency.

Purpose of the Study:

  • To discuss the role and limitations of imaging in antirheumatic drug trials.
  • To highlight the advantages of sensitive imaging techniques for detecting early therapeutic effects.
  • To consider the practical constraints of implementing advanced imaging in large-scale, multicenter drug studies.

Main Methods:

  • Review of current practices in antirheumatic drug clinical trials.

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  • Discussion of the capabilities of conventional radiology versus newer imaging modalities.
  • Analysis of the impact of trial scale and cost on imaging technique selection.

    • Main Results:

    • Conventional radiology is still widely used in drug trials due to logistical and economic factors.
    • Advanced imaging techniques offer greater sensitivity for detecting early disease modifications.
    • Newer antirheumatic drugs with specific actions may benefit from imaging that assesses changes in synovium, cartilage, bone, and soft tissues.

    Conclusions:

    • The choice of imaging in antirheumatic drug trials balances the need for sensitivity with practical considerations like cost and accessibility.
    • Future trials may benefit from incorporating more sensitive imaging to evaluate novel therapeutics.
    • Developing cost-effective, accessible advanced imaging methods is important for future clinical research in rheumatology.