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Synthesis and properties of some aryloxyaminoalkanes
H Marona1, L Gajewczyk, B Filipek
1Department of Chemical Technology of Drugs, Collegium Medicum, Jagiellonian University, Kraków, Poland.
Acta Poloniae Pharmaceutica
|January 1, 1996
Abstract:
New aryloxyaminoalkanes Ia-f and VI were prepared by O-alkylation of either the appropriate phenols using (R,S)-N-(1-bromo-2-butyl)-phthalimide or in reaction of (R,S)-N-(2-hydroxy-1-butyl)-phthalimide [II] with the use of 4-chloronitrobenzene. The structure of the synthesized compounds was verified by elemental analysis, IR, 1H NMR and mass spectral data. Compounds Ia, Id and Ie were subjected to preliminary pharmacological studies on the circulatory system activity.