Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perforated colorectal cancer

S Kriwanek1, C Armbruster, K Dittrich

  • 1First Department of Surgery, Rudolfstifung-Hospital, Vienna, Austria.

Diseases of the Colon and Rectum
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correspondence.

The British journal of surgery·2019
Same author

Letter Regarding "Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature" by Y. Tu et al.

Seminars in ophthalmology·2015
Same author

Strategies to induce cardiac differentiation of Mesenchymal Stem Cells.

Journal of stem cells & regenerative medicine·2014
Same author

Somatic cell reprogramming by transfection with liposomal agents.

Journal of stem cells & regenerative medicine·2014
Same author

Formation of multilayered vesicles from water/organic-solvent (w/o) emulsions: theory and practice.

Pharmaceutical research·2013
Same author

Health impact in children and adolescents.

Best practice & research. Clinical endocrinology & metabolism·2013
Same journal

A Penny for Your Thoughts.

Diseases of the colon and rectum·2026
Same journal

June 2026 Translations.

Diseases of the colon and rectum·2026
Same journal

Selected Abstracts.

Diseases of the colon and rectum·2026
Same journal

Recurrence After Rectopexy: Insights From Magnetic Resonance Defecography.

Diseases of the colon and rectum·2026
Same journal

Risk of Metabolic Disease After Right- vs Left-Sided Colectomy for Colon Cancer: A Nationwide Cohort Study.

Diseases of the colon and rectum·2026
Same journal

Sexual Distress Is Common in Long Term Follow-up After Pelvic Pouch for Ulcerative Colitis: A Cross-Sectional Study.

Diseases of the colon and rectum·2026
See all related articles

Colorectal cancer perforation is a severe complication with high mortality. Advanced stages and sepsis significantly impact outcomes, making these patients the highest risk group for colonic perforation.

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Oncology

Background:

  • Colorectal cancer perforations are rare but life-threatening complications.
  • Mortality rates for perforated colorectal cancer range from 30% to 40%.

Purpose of the Study:

  • To identify prognostic indicators and causes of death in perforated colorectal cancer.
  • To assess the risk associated with perforated colorectal tumors.
  • To compare outcomes of perforated cancers with uncomplicated cancers and benign perforations.

Main Methods:

  • Retrospective analysis of 35 patients with perforated colorectal cancers.
  • Comparison with 868 patients with uncomplicated cancers and 130 patients with benign large-bowel perforations.
  • Evaluation of postoperative survival based on peritonitis, septic state, and tumor stage.

Related Experiment Videos

Main Results:

  • Perforated colorectal cancers presented with advanced tumor stages, increased septic organ failures, and higher mortality rates compared to other groups.
  • Long-term survival was influenced by tumor stage but showed no significant difference between perforated and uncomplicated cancers.
  • Mortality in perforated cancers was 40%.

Conclusions:

  • The high postoperative mortality in malignant perforation is likely due to the combined effects of malignancy and sepsis.
  • Patients with perforated colorectal cancer represent the highest-risk group among all colonic perforations.