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Related Experiment Video

Updated: Oct 6, 2025

Cell-cell Fusion of Genome Edited Cell Lines for Perturbation of Cellular Structure and Function

Cell-cell Fusion of Genome Edited Cell Lines for Perturbation of Cellular Structure and Function

Published on: December 7, 2019

Virus-cell and cell-cell fusion

L D Hernandez¹, L R Hoffman, T G Wolfsberg

¹Department of Cell Biology, University of Virginia, Charlottesville 22908, USA.

Annual Review of Cell and Developmental Biology

|January 1, 1996

Summary

This summary is machine-generated.

Viral fusion proteins undergo conformational changes to expose fusion peptides, initiating membrane fusion. Cell-cell fusion mechanisms are less understood, but ADAM proteins are potential candidates.

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Method for Measurement of Viral Fusion Kinetics at the Single Particle Level

Method for Measurement of Viral Fusion Kinetics at the Single Particle Level

Published on: September 7, 2009

Area of Science:

Biochemistry
Molecular Biology
Cell Biology

Background:

Viral membrane fusion proteins are crucial for infection and have distinct pH-dependent mechanisms.
Understanding viral fusion mechanisms provides insights into cellular fusion processes.

Purpose of the Study:

To review the mechanisms of viral membrane fusion proteins.
To discuss the potential role of ADAM proteins in cell-cell fusion.

Main Methods:

Literature review of viral fusion protein mechanisms.
Analysis of evidence for triggered conformational changes and fusion peptide exposure.
Identification of candidate cell-surface proteins involved in fusion.

Main Results:

Viral fusion proteins utilize triggered conformational changes to expose fusion peptides, facilitating bilayer interaction.
Low and neutral pH-dependent fusion mechanisms are increasingly understood.
ADAM family proteins are emerging as candidates for mediating cell-cell fusion.

Conclusions:

Viral fusion protein mechanisms provide a framework for understanding membrane fusion.
Further research into ADAM proteins is needed to confirm their role in cell-cell fusion.