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Intravitreal tolerance of a new perfluorocarbon vitreous replacement, Multifluor APF-144
G A Peyman1, M Soheilian, Q Luo
1LSU Eye Center, Louisiana State University Medical, Center School of Medicine, New Orleans 70112-2234, USA.
Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|December 1, 1996
Summary
This study found that Multifluor APF-144, a new perfluorocarbon vitreous substitute, demonstrated good intravitreal tolerance in rabbits. It shows potential as a short-term retinal tamponade after surgery.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Retinal Surgery
Background:
- Perfluorocarbons are utilized in vitreoretinal surgery.
- Evaluating novel perfluorocarbon compounds for ocular applications is crucial.
Purpose of the Study:
- To assess the intravitreal tolerance and safety of Multifluor APF-144 (perfluorotetramethylcyclohexane) as a vitreous replacement.
- To investigate the potential of Multifluor APF-144 as a short-term postoperative retinal tamponading agent.
Main Methods:
- Vitrectomy was performed on ten New Zealand albino rabbits.
- Five eyes were filled with Multifluor APF-144, and five received saline as a control.
- Ophthalmoscopy, electroretinography, and light/electron microscopy were used for evaluation.
Main Results:
- No cases of endophthalmitis were observed.
- Electroretinography showed no significant changes in the experimental group.
- Microscopic examination revealed no retinal toxicity.
Conclusions:
- Multifluor APF-144 exhibits favorable intravitreal tolerance.
- The compound is a promising candidate for short-term retinal tamponade in postoperative care.