Related Experiment Videos
Blood velocity in an experimental iris tumor
G A Peyman1, B Khoobehi, A Moshfeghi
1Louisiana State University Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans 70112-2234, USA.
Ophthalmic Surgery and Lasers
|June 26, 1998
Summary
This study visualized tumor vasculature in rabbits using fluorescent microsphere angiography (FMA). Slower blood flow was observed in tumor vessels, aiding understanding of hyperthermia therapy and drug delivery.
Area of Science:
- Ophthalmology
- Oncology
- Vascular Biology
Background:
- Greene strain melanoma implanted in rabbit irides.
- Eight nonpigmented rabbits used for study.
Purpose of the Study:
- Evaluate blood flow in tumor vasculature.
- Assess tumor vascular efficiency and blood velocity.
Main Methods:
- Conventional scanning laser ophthalmoscopy.
- Fluorescent microsphere angiography (FMA) for visualization.
- SVHS videotape analysis of microsphere movement and blood velocity.
Main Results:
- Tumor vasculature was poorly organized and inefficient.
- Tumor blood velocity was significantly slower (up to 2.5x) than normal iris vasculature (P = .05).
- Tumor blood flow visualized in real-time.
Conclusions:
- Poorly organized tumor vasculature and reduced blood velocity explain hyperthermic therapy success.
- Findings may guide development of targeted drug delivery systems.
- Potential for improved tumoricidal agents and therapies.