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The immunology of Eta-1/osteopontin
1Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Cytokine & Growth Factor Reviews
|October 1, 1996
Abstract:
The cytokine Eta-1/osteopontin is secreted by activated macrophages and may constitute the most abundant molecule secreted by activated T-lymphocytes. It causes macrophages to migrate and suppress production of reactive oxygen species. It enhances generation of immunoglobulins or proliferation of B-lymphocytes. Its biochemical characteristics suggest that Eta-1/osteopontin may be the T-lymphocyte suppressor factor. The apparently conflicting effects on individual immune functions may reflect homeostatic mechanisms.
