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Updated: Aug 18, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
Published on: April 3, 2013
[Rosette formation in explants of human embryonic neocortex (an electron-microscopic study)]
Abstract:
Multiple invaginations and closed cavities (rosettes) were developed in 199 fragments of wall of human anterior cerebral vesicle. Contraction of neuroepithelial cells apexes after the principle of the gathered tobacco pouch was involved into the process. This confirms the previous suggestion of the authors on the similarity between the mechanisms of rosettes forming and neurulation. The participation of radial glia cells and neuroblasts in the reorganization of the neocortex germ was also studied.
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