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Three-part inventions: intracellular signaling and induced proximity
1Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, CA 94305-5428, USA. hf.grc@forsythe.stanford.edu
Trends in Biochemical Sciences
|November 1, 1996
Abstract:
Everyone has had the experience of stoking a fire; putting the logs close together causes flames to appear from previously dying embers. In a similar way, mere proximity might mediate qualitative biological responses. We discuss natural molecules that appear to have arisen to bring two proteins together and illustrate how this simple mechanism can be used to control a wide variety of biological processes.