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Adaptive mutation: a general phenomenon or special case?

S Benson1

  • 1Dept of Microbiology, University of Maryland, College Park 20742, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|January 1, 1997
PubMed
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Adaptive reversion of bacterial mutations is rare, not a general rule. However, some mutations showed more late revertants than expected, suggesting adaptive mutability in chromosomal genes.

Area of Science:

  • Microbiology
  • Genetics
  • Bacterial Evolution

Background:

  • Adaptive reversion, the appearance of late revertant colonies, has been observed in bacteria.
  • Previous studies suggested adaptive mutability might be limited to extrachromosomal elements like plasmids and phages.

Purpose of the Study:

  • To investigate the phenomenon of adaptive reversion in chromosomal genes of Salmonella typhimurium LT2.
  • To determine if adaptive mutability applies to chromosomal mutations beyond extrachromosomal elements.

Main Methods:

  • Classical genetic analysis of Salmonella typhimurium LT2.
  • Characterization of adaptive reversion in various types of mutations (nonsense, missense, frameshift, insertion).
  • Quantification of late revertant colonies.

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Main Results:

  • Adaptive reversion was found to be an exception, not a general phenomenon for chromosomal mutations.
  • Certain specific mutations exhibited a higher number of late revertants than predicted by standard models.
  • These findings indicate that adaptive mutability can occur in chromosomal genes.

Conclusions:

  • Adaptive reversion is not a widespread mechanism for chromosomal gene mutations in Salmonella typhimurium.
  • The observed excess of late revertants for specific mutations suggests a role for adaptive mutability in chromosomal DNA.
  • This implies that adaptive mutability may be a more general phenomenon in bacteria than previously thought, extending to chromosomal genes.