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Mass spectrometry in protein studies from genome to function
1Department of Molecular Biology, Odense University, DK 5230 Odense M, Denmark. roe@pr-group.ou.dk
Current Opinion in Biotechnology
|February 1, 1997
Summary
New mass spectrometry advancements offer femto- to attomole sensitivity for biochemistry and biotechnology. This technique is crucial for proteome analysis, protein structure studies, and protein interactions.
Area of Science:
- Biochemistry
- Molecular Biology
- Biotechnology
Background:
- Growing need for highly sensitive and specific analytical techniques in life sciences.
- Mass spectrometry (MS) is an established tool for studying protein modifications.
Purpose of the Study:
- To highlight recent advancements in mass spectrometry.
- To discuss the expanding role of MS in various levels of protein studies.
Main Methods:
- Development of new mass spectrometry techniques.
- Routine achievement of femto- to attomole sensitivity.
- Attainment of low parts per million mass accuracy.
Main Results:
- Mass spectrometry now routinely provides exceptional sensitivity and mass accuracy.
- MS is becoming indispensable for comprehensive protein analysis.
Conclusions:
- Mass spectrometry is a key technology meeting analytical demands in biochemistry, molecular biology, and biotechnology.
- Future applications of MS will encompass proteome analysis, higher-order protein structures, and protein interaction studies.