Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hepatoxicity caused by flutamide increased by hypotensive situation?]

N Serrano Hernández1, F García López, J Fedriani Gorria

  • 1Unidad de Medicina Intensiva, Hospital General, Albacete.

Anales De Medicina Interna (Madrid, Spain : 1984)
|November 1, 1996
PubMed
Summary

Flutamide, an antiandrogen drug, may cause severe liver damage (hepatotoxicity) when combined with hypotension. This case highlights the risk of drug-induced liver injury in patients with cardiovascular conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obesity and renal function. Data from the epidemiological study: Prevalence of chronic renal disease in Spain. EPIRCE Study.

Nefrologia·2018
Same author

[Nefrología 2008-2009].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia·2009
Same author

[The supplements of Evidence-Based Nephrology as a tool for continual medical education].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia·2008
Same author

[Is the combination aliskiren /valsartan as effective and safe as either drug in monotherapy for treating hypertension?].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia·2008
Same author

[Has the prevalence of chronic renal disease increased in recent years?].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia·2008
Same author

[Is a very low protein diet effective in delaying starting on dialysis in the elderly?].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia·2008

Area of Science:

  • Hepatology
  • Pharmacology
  • Cardiology

Background:

  • Flutamide is an antiandrogen medication used in prostate cancer treatment.
  • Hepatotoxicity is a known, albeit rare, adverse effect of flutamide therapy.
  • Hypotension can exacerbate existing organ damage by reducing oxygen supply.

Observation:

  • A 76-year-old male experienced acute, life-threatening hepatotoxicity.
  • The patient had been taking flutamide for 10 months.
  • The liver injury occurred during a period of moderate hypotension due to atrial flutter.

Findings:

  • Significant elevations in AST (4,521 IU/L) and ALT (1,716 IU/L) were observed.
  • Prothrombin activity dropped to 16%, indicating severe liver dysfunction.
  • Thrombocytopenia and hemorrhages were also present.

Related Experiment Videos

Implications:

  • Hypotension may trigger severe hepatotoxicity in patients with subclinically flutamide-damaged hepatocytes.
  • Mechanisms may involve impaired mitochondrial respiration and toxic metabolite formation (cytochrome P450-mediated).
  • This case underscores the importance of monitoring liver function in patients on flutamide, especially those with cardiovascular risk factors.