[The ANLL-NS 02 protocol for individualized therapy in acute nonlymphoblastic leukemia]

ANLL-NS-02 program is intended for individualized therapy of patients with acute non-lymphoblastic leukemia. The program itself is based on a net of prognostic models providing prompt prognosis of bad outcome of the disease as well as their prevention or early treatment. Specific prevention of early death is conducted prior to and during the induction therapy. Prevention of resistance to cytostatic drugs is based on evaluation of the early effect of the first induction chemotherapy with three cytologic-mathematical parameters. Remission consolidation consists of two individualized courses. Older patients undergo maintenance therapy which differs in clonal and nonclonal remissions. Optimal time to perform bone marrow transplantation is determined by mathematical models based on clinical data. In patients with high risk of leukemic relapse, transplantation is performed in the first remission, while in others it is performed in eventual relapse. Parts of ANLL-NS-02 program are computerized and adapted for clinical utilization. This program has been used at our institution for 5 years and results have confirmed advantages of individualized therapy over standard protocols in treating acute non-lymphoblastic leukemia.